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Representative articles


2010 was a productive year in terms of publications. Representative articles are listed below. In addition numerous presentations were made at national and international scientific meetings.

Book Chapters

1. Joyce M,  O’ Connell PR Ano-rectal stenosis: in Givel JC, Mortensen NMcC, Roche B eds  Anorectal and colonic diseases: a practical guide to their management. 2010 Springer-Verlag, Heidleberg, 651-658

2. O’Connell PR, Sheehan G Intra-abdominal sepsis, peritonitis and pancreatitis in Cohen J, Powderly WG Opal SM eds Infectious Diseases 3rd Edition, 2010 Mosby Elsevier 800-807

Significant Publications

1. Peirce C, Buffini M, O'Herlihy C, O'Connell PR, Jones JF. Central representation of the  inferior rectal nerve in the rat Dis Colon and Rectum, 2010 Mar;53(3):315-320

2. Burke J, Coffey JC, Docherty NG, O’Connell PR Endoglin negatively regulates tgf-β1 induced profibrotic responses in intestinal fibroblasts.Br J Surg 2010 Jun;97(6):892-901

3. Cunningham M, Docherty NG, Coffey JC, O’Connell PR Post-surgical recurrence of ileal Crohn’s disease: an update on risk factors and interventions points to a central role for impaired host-microflora homeostasis World J of Surgery  2010;34:1615-26

4. Burke JP, Cunningham MF, Watson RWG, , Docherty NG, Coffey JC, O’Connell PR
Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts. Br J Surg 2010; 97: 1126-34

5. Griffin KM, Blau  C, Kelly M, O’Herlihy C,. O’Connell P.R . Jones JF,  Kerskens C
Propofol allows precise quantitative arterial spin labelling functional magnetic resonance imaging in the rat Neuroimage 2010 Jul 15;51(4):1395-404

6. Cunningham MF, Docherty NG, Burke JP , O’Connell PR. S100a4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn’s disease and promotes intestinal fibroblast migration Am J Physiology, 2010 Aug;299(2):G457-66

7. Buffini M, O’Halloran KD, O’Herlihy C, O’Connell R, Jones JF Comparison of the contractile properties, oxidative capacities and fibre type profiles of the voluntary sphincters of continence in the rat J. Anatomy 2010, 217:187-195

8. Rowan FE, Docherty NG, Coffey JC, Murphy M, Murphy B, O’Connell PR  Desulfovibrio bacterial species are increased in ulcerative colitis Dis Colon Rectum, 2010; 53:1530-6

9. Rowan FE, Docherty NG, Coffey JC, Murphy M, Murphy B, O’Connell PR
Culture independent quantification of total bacterial colonization of colonic crypts in patients with ulcerative colitis and controls Ann Surg 2010, 252, 869-875
10. Medani M, Docherty NG, O’Connell PR, Winter DC  the emerging role of
       hydrogensulphide in colonic physiology and  pathophysiology  Inflammatory Bowel
       Disease 2010 Nov 8. [Epub ahead of print] PMID: 21061381

11. Donohoe CL, Brannigan AE, O'Connell PR.  Palliative endoscopic trans-anal resection of advanced   rectosigmoid carcinoma.  Ir J Med Sci. 2010 Oct 17. [Epub ahead of print]PMID: 20953977

12. Shields CJ, Tiret E, Winter DC, Baum RP, Mortensen N, Fazio VW, Stocchi L,
Sheahan K, O’Keane C, Brannigan A, O’Connell PR, Parc Y, Mourra N,Garcia-Olmo D, Soreide K, Prasad V, Kaemmerer D, Flemming M, Sagar P. Carcinoid tumours of the rectum – a multi-institutional interantional collaboration Ann Surg, 2010; 252: 750-755
13. Mulsow J, Winter DC. Extralevator abdominoperineal resection for low rectal cancer: new direction or miles behind? Arch Surg. 2010 Sep;145(9):811-3.

14. Smith FM, Waldron D, Winter DC. Rectum-conserving surgery in the era of chemoradiotherapy. Br J Surg. 2010 Dec;97(12):1752-64.

15. Coneely J, Kennelly R, Bouchier-Hayes D, Winter DC. Mast cell degranulation is essential for anastomotic healing in well perfused and poorly perfused rat colon. J Surg Res. 2010 Nov;164(1):e73-6.

16. Kennelly R, Conneely JB, Bouchier-Hayes DJ, Winter DC. Electrical field stimulation promotes anastomotic healing in poorly perfused rat colon. Int J Colorectal Dis. 2011 Mar;26(3):339-44.

17. Hennessey DB, Burke JP, Ni-Dhonochu T, Shields C, Winter DC, Mealy K. Preoperative hypoalbuminemia is an independent risk factor for the development of surgical site infection following gastrointestinal surgery: a multi-institutional study. Ann Surg. 2010 Aug;252(2):325-9.

18. Oon SF, Winter DC. Perianal condylomas, anal squamous intraepithelial neoplasms and screening: a review of the literature. J Med Screen. 2010;17(1):44-9.
Ali M, Winter DC, Hanly AM, O'Hagan C, Keaveny J, Broe P. Prospective, randomized, controlled trial of thoracic epidural or patient-controlled opiate analgesia on perioperative quality of life. Br J Anaesth. 2010 Mar;104(3):292-7.

19. Hogan AM, Collins D, Sheehan K, Zierau O, Baird AW, Winter DC. Rapid effects of phytoestrogens on human colonic smooth muscle are mediated by oestrogen receptor beta. Mol Cell Endocrinol. 2010 May 14;320(1-2):106-10.

20. Deasy J, Prichard RS, Evoy D, McDermott EW. The role of thyrotropin suppression in patients with differentiated thyroid carcinoma. Ir Med J. 2010;103(7):202-5.

21. Duffy MJ, Evoy D, McDermott EW. CA 15-3: uses and limitation as a biomarker for breast cancer. Clin Chim Acta. 2010 Dec 14;411(23-24):1869-74.

22. Dillon MF, Hayes BD, Quinn CM, Advani V, Masterson C, Evoy D, McDermott EW. The Extent of Axillary Lymph Node Clearance Required Following Detection of Sentinel Node Micrometastases. Breast J. 2010 Jul 6. [Epub ahead of print]
PMID: 20626393

23. Pierce A, Saldova R, Abd Hamid UM, Abrahams JL, McDermott EW, Evoy D, Duffy MJ, Rudd PM. Levels of specific glycans significantly distinguish lymph node-positive from lymph node-negative breast cancer patients. Glycobiology. 2010 Oct;20(10):1283-

24. Myers E, Kavanagh DO, Ghous H, Evoy D, McDermott EW. The impact of evolving management strategies on negative appendicectomy rate. Colorectal Dis. 2010 Aug;12(8):817-21.

25. Prichard RS, Haren A, Evoy D, McDermott E. Physician's initial impression of elderly breast cancer patients allows appropriate treatment stratification despite lack of quantitative assessment. Ir Med J. 2010 Nov-Dec;103(10):314-6.

26. McKiernan E, McDermott EW, Evoy D, Crown J, Duffy MJ. The role of S100 genes in breast cancer progression. Tumour Biol. 2011 Jun;32(3):441-50.

27. MacGiobhuin, Kavanagh DO, Myers E, Doherty AO, Quinn CM, Crotty T, Evoy D, McDermott EW. Removal of multiple sentinel lymph nodes in patients with breast cancer: defining the "correct" node. Acta Chir Belg. 2010 Mar-Apr;110(2):185-8.

28. Rock K, Fattah N, O'Malley D, McDermott E. The management of acute parathyroid crisis secondary to parathyroid carcinoma: a case report. J Med Case Reports. 2010 Jan 29;4(1):28.

29. Kavanagh DO, McIlroy M, Myers E, Bane F, Crotty TB, McDermott E, Hill AD, Young LS. The role of oestrogen receptor {alpha} in human thyroid cancer: contributions from coregulatory proteins and the tyrosine kinase receptor HER2. Endocr Relat Cancer. 2010 Feb 18;17(1):255-64.

30. Myers E, Kavanagh DO, Ghous H, Evoy D, McDermott EW. The impact of evolving management strategies on negative appendicectomy rate. Colorectal Dis. 2010 Aug;12(8):817-21.