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  • Real world Clinical Outcomes with Novel Modulator Therapy Combinations in People with CF (RECOVER).

    This study will examine the impact of TCM on various aspects of the lives and health of adults with cystic fibrosis. (Triple combination CFTR modulator therapy (TCM).

    1. Status: Not-Recruiting
  • The TOPaz Study

    This study aims to investigate if a two year spell of treatment with a drug call Teriparatide, followed by one dose of treatment called Zoledronic Acid can reduce the risk of broken bones (fractures) in Osteogenesis Imperfecta (brittle bone disease). We are comparing this treatment with the usual treatment that patients with OI normally receive.

    1. Status: Open Recruiting
  • Treatment of invasively ventilated adults with Early Activity and Mobilisation – TEAM Trial

    The sickest patients in intensive care units (ICU) receive prolonged, invasive support for their breathing. This is commonly managed with no active exercise out of bed, and results in severe muscle weakness, longer hospital stay and poor recovery. We have found that early activity and mobilisation during invasive breathing support is safe and may improve survival and recovery. We will test whether early activity and mobilisation is really better.

    1. Status: Open Recruiting

    To compare viral load outcomes on DTG/RPV FDC regimen (experimental arm) to continued ART regimen (control arm) at 48 weeks as measured by HIV-1 RNA below or confirmed above 50 copies/Ml.

    1. Status: Closed

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