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  • A Study Evaluating the Long-term Safety and Efficacy of Vx-659 Combination Therapy

    A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-659 Combination Therapy in Subjects with Cystic Fibrosis who are Homozygous or Heterozygous for the F508del Mutation

    1. Status: Open Recruiting
  • BUR02

    This study aims to establish the long-term safety and tolerability profile of Burosumab in the treatment of adults with XLH and to provide continued treatment for subjects previously enrolled in UX023-CL303 and UX023-CL304 clinical trials.

    1. Status: Open Recruiting
  • COVIRL-002

    Key Eligibility Criteria Aged 18 years or older Inpatient hospitalisation Confirmed SARS-CoV2(COVID-19) Infection Evidence of hyper-inflammatory state and pulmonary infiltrates on chest imaging. Moderate to severe respiratory failure.

    1. Status: Open Recruiting
  • The TOPaz Study

    This study aims to investigate if a two year spell of treatment with a drug call Teriparatide, followed by one dose of treatment called Zoledronic Acid can reduce the risk of broken bones (fractures) in Osteogenesis Imperfecta (brittle bone disease). We are comparing this treatment with the usual treatment that patients with OI normally receive.

    1. Status: Open Recruiting
  • Treatment of invasively ventilated adults with Early Activity and Mobilisation – TEAM Trial

    The sickest patients in intensive care units (ICU) receive prolonged, invasive support for their breathing. This is commonly managed with no active exercise out of bed, and results in severe muscle weakness, longer hospital stay and poor recovery. We have found that early activity and mobilisation during invasive breathing support is safe and may improve survival and recovery. We will test whether early activity and mobilisation is really better.

    1. Status: Open Recruiting