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  • A Study Evaluating the Long-term Safety and Efficacy of Vx-659 Combination Therapy

    A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-659 Combination Therapy in Subjects with Cystic Fibrosis who are Homozygous or Heterozygous for the F508del Mutation

    1. Status: Open Recruiting
  • BUR02

    This study aims to establish the long-term safety and tolerability profile of Burosumab in the treatment of adults with XLH and to provide continued treatment for subjects previously enrolled in UX023-CL303 and UX023-CL304 clinical trials.

    1. Status: Open Recruiting
  • Omics Study of Psoriasis and Atopic Dermatitis

    Psoriasis and atopic Dermatitis are inflammatory skin diseases. With this research study we hope that we will be able to understand the mechanism of these skin diseases in patients and determine the key factors in the body which may cause the progression of the disease by comparing healthy subjects against subjects with either psoriasis or atopic dermatitis

    1. Status: Open Recruiting

    This Clinical trial will investigate if Semaglutide has an effect on reducing cardiovascular events e.g. heart attack or stroke in overweight or obese patients.

    1. Status: Open Recruiting
  • The TOPaz Study

    This study aims to investigate if a two year spell of treatment with a drug call Teriparatide, followed by one dose of treatment called Zoledronic Acid can reduce the risk of broken bones (fractures) in Osteogenesis Imperfecta (brittle bone disease). We are comparing this treatment with the usual treatment that patients with OI normally receive.

    1. Status: Open Recruiting
  • Treatment of invasively ventilated adults with Early Activity and Mobilisation – TEAM Trial

    The sickest patients in intensive care units (ICU) receive prolonged, invasive support for their breathing. This is commonly managed with no active exercise out of bed, and results in severe muscle weakness, longer hospital stay and poor recovery. We have found that early activity and mobilisation during invasive breathing support is safe and may improve survival and recovery. We will test whether early activity and mobilisation is really better.

    1. Status: Open Recruiting
  • Usage of Omics Technology for Identification of Critical Mediators and Pathways in Patients with Hidradenitis Suppurativa (HS)

    Hidradenitis suppurativa is an inflammatory skin disease affecting approximately 1% of the population and Adalimumab (Humira) is a medication that has been licenced for the treatment of patients with HS. We are trying to further understand how Humira works in HS. We hope to determine the factors in the body which may cause improvements for the disease with Humirea treatments

    1. Status: Open Recruiting
  • VAY736 Study

    Phase II study looking at the efficacy, safety and tolerability of VAY736 in patients with idiopathic pulmonary fibrosis. It is hoped in this double-blind study to assess the safety of VAY736 and if it has beneficial effects in people who have idiopathic pulmonary fibrosis. The purpose of this study is to determine if VAY736 will improve Lung function.

    1. Status: Open Recruiting